Tab3

Uptake transporters
Solute carrier family 10
Name	Species	mRNA	AA	Mr	Chromosome	Assession-Nr	Homology	Expression	Localization
NTCP SLC10A1	human	1.7	349	50	14q24.1- 24.2	NM_003049	with	L	basolateral
Ntcp	rat	1.8	362	51	6q24	M77479	77% (NTCP)	L	basolateral
ISBT SLC10A2	human	1.2	348	48	13q33	NM_000452		I	apical
Isbt	rat	1.2	348	48	?	U07183		I	apical
Solute carrier family 22
Name	Species	mRNA	AA	Mr	Chromosome	Assession-Nr	Homology	Expression	Localization
OCT1 SLC22A1	human	1.9	554	62	6q26	NM_003057	80% (rOct1)	L,K	basolateral
Oct1	mouse				17
Oct1	rat	1.9/3.4	556	62	1q11-12	X78855	with	L,K	basolateral
OCT2 SLC22A2	human	2	554	?	6q26	NM_003058	70% (OCT1)	K	?
Oct2	mouse			?	17				?
Oct2	rat	2.1	593	?	?	D83044	67% (rOct1)	K	?
OCT3 SLC22A3	human	3.5?			6q26-q27	AF078749			?
Oct3	mouse	3.5?			17	AF078748		P,I,B	?
Oct3	rat	3.5	551	62?	?	AF055286		P,I,B	?
OCTN1 SLC22A4	human	2.1	551	?	5	NM_003059		widely	?
OCTN2 SLC22A5	human	3.5	557	?	5q31	NM_003060	75.8% (OCTN1)	widely	?
OCTL3	human	>2.6	551		3p21/22	NM_004256		widely	?
OCTL4	human	>2.2	594		3p21/22	NM_004803		widely	?
Octn2 ct1	rat	3.0	557	?	?	AB017260	85% (OCTN2)	K,L,Co	?
USTr1	rat	2.6	552	62?	?	Y09945			?
Rst	mouse	1.8	553	?		AB005451	30% (rOct1)	K
OAT-1 SLC22A6	human	1.6	550	?	11q13.1	NM_004790	38% (OCT1)	K	basolateral
Oat-1	rat	2.2	551	?	?	AB004559		K	basolateral
Oat-1	mouse	2.5	546	?	19	U52842	93% (rOat1)	K	basolateral
OAT-2 SLC22A7	human	2.1	548	?	?	NM_006672	42% (OAT1)	L	basolateral?
Oat-2	rat	2.0	535	?	?	L27651 L30107	42% (rOat1)	L	basolateral?
OAT-3 SLC22A8	human	1.7	568	?	11q11-q12	NM_004254		K	basolateral?
Oat-3	mouse	2	537	?	19	AF078869	84% (OAT3)	K	basolateral?
Solute carrier family 21
Name	Species	mRNA	AA	Mr	Chromosome	Assession-Nr	Homology	Expression	Localization
SLC21A1	human					?
Slc21a1 Oatp1	rat	2.7	670	80		L19031	67% (OATP-A)	L	basolateral
Slc21a1 Oatp1	mouse	2.01	670	80	XA3-A5	NM_013797 NP_038825	81% (rOatp1)	L	basolateral
SLC21A2 PGT	human	4.2/2.3	643	?	3q21	NM_005630 NP_005621	82% (Pgt)	widely	basolateral?
Slc21a2	rat	4.7/4	643	?		M64862	37% (rOatp1)	widely	basolateral?
SLC21A3 OATP-A, OATP	human	2.7	670	80	12p12	NM_005075 NP_005066		BBB	basolateral
SLC21A4	human					?
Slc21a4 Oat-K1/K2	rat	>2.8	669	?	?	D79981 AB012662	72% (rOatp1)	K	apical
SLC21A5	human					?
Slc21a5 Oatp2	rat	3.64	661	80	?	U88036	77% (rOatp1)	L	basolateral
SLC21A6 OATP-C, LST-1	human	>2.5	691	?	12	NM_006446 NP_006437		L	basolateral?
SLC21A7	human					?
Slc21a7 Oatp3	rat	2.5	670	80	?	AF041105		I	basolateral?
SLC21A8	human					?
SLC21A9 OATP-B	human	>2.4	709	?	11q13	NM_007256 NP_009187		BBB	basolateral?
SLC21A10	human					?
Slc21a10 Oatp4, Lst-1	rat	3.2	687	?	?	AJ271682 CAB92299		L	basolateral?
SLC21A11 OATP-D	human	2.7	710	?	15q26	NM_013272 NP_037404		kidney	basolateral
SLC21A12	human					?
SLC21A13	human					?
Slc21a13 Oatp5	rat	2.5	670		?	AF053317
SLC21A14 OATP-F	human	3	712		12	NM_017435 NP_059131
Export (ABC)-transporters (see also here!)
MDR/TAP (ABC subfamily B)
Name	Species	mRNA	AA	Mr	Chromosome	Assession-Nr	Homology	Expression	Localization
MDR1 ABCB1	human	4.5	1280	170	7q21	NM_000927 M14758 (G->V)	78% (Mdr1b)	L,K,I,BBB	apical
Mdr1a Abcb1a	mouse	4.3	1276	170	5	M33581	82.2% (MDR1)	L,K,I,BBB	apical
Mdr1a Abcb1a	rat	4.3	1272	170	4q11-12	AF257746	83% (MDR1)	L,K,I,BBB	apical
Mdr1b Abcb1b	mouse	4.3	1276	170	5	M14757	84.2% (Mdr1a)	L,Lu,I	apical
Mdr1b Abcb1b	rat	4.3	1277	170	4q11-12	M62425	79% (MDR1)	L,Lu,I	apical
MDR2/3 ABCB4	human	4.5	1279	170	7q21	NM_000443	74.9% (MDR1)	L	apical
Mdr2 Abcb4	mouse	4.5	1276	170	?	J03398	69.4% (Mdr1b)	L	apical
Mdr2 Abcb4	rat	4.5	1278	170	4q11-12	L15079	72.1% (Mdr1b)	L	apical
BSEP ABCB11	human	5.4	1321	170	2q24	NM_003742	88% (rat)	L	apical
Bsep Abcb11	mouse	5	1321	160	2	AF133903	94% (rat) 89% (human)	L	apical
Bsep Abcb11	rat	5.4	1321	160	?	U69487 AF010597	48% (Mdr2)	L	apical
CFTR/MRP (ABC subfamily C)
Name	Species	mRNA	AA	Mr	Chromosome	Assession-Nr	Homology	Expression	Localization
MRP1 ABCC1	human	6.5	1531	190	16p13.12-13	NM_004996	19% (CFTR)	widely	lateral
Mrp1 Abcc1	mouse	6-6.2	1528	185	?	AF022908	84% (MRP1)	widely	lateral
MRP2 ABCC2	human	6.5	1545	200	10q24	NM_000392	46% (MRP1)	L,K,I	apical
Mrp2 Abcc2	rat	6.5	1541	200	?	L49379 X96393 D86086	48% (MRP1)	L,K,I	apical
MRP3 ABCC3	human	6.5	1527	200	17q21.3	NM_003786	58% (MRP1)	L,K,I	basolateral
Mrp3 Abcc3	rat	6.5	1523	?	?	AB010467 U73038 AF072816	-	L,K,I	basolateral
MRP4 ABCC4	human	>4.2	1325	?	13q31/32	NM_005845	-		?
MRP5 ABCC5	human	6.6?	1437	?	3q27	NM_005688	-		?
Mrp5 Abcc5	mouse	5.4	1436	?	?	AB019003			?
Mrp5 Abcc5	rat	5.75	1436	?	?	AB020209			?
MRP6 ABCC6	human	6.5 (4.5)	1503	?	16p13	AF076622	-	L,I	lateral
Mrp6 Abcc6	mouse	5	1498	?	?	AB028737		L,I	lateral
Mrp6 Abcc6	rat	5.8	1502	?	?	AB010466 U73038	-	L,I	lateral

Human Genome Nomenclature	ABC-transporter Nomenclature	Genetic Maps of the Rat Genome	The rat genome database
MGD	OMIA	EcoCyc	SGD
The Swine Genome Map	Flybase	C. elegans	Zebrafish
GDB	Human ESTs	MIPS	EMBL WWW Services
OMIM	LocusLink	GENATLAS	GeneCards
Basic Blast	ExPasy Tools	TRANSFAC	PubMed
Paul Watkins Lab (some informations on transporter specificity)
The Yeast Transport Protein Database	Milton Saier's Transport Protein Classification	E. Coli ABC TRANSPORTER ATPase MOTIF II/III	Whitehead Institute for Biomedical Research

with official gene symbols (update: july-2000)