promoter

Transporter	Ass. Nr.	Sites	References
ABCA1	AF258623 AJ252201	LXR/RXR	Pullinger CR, et al. Analysis of hABC1 gene 5' end: additional peptide sequence, promoter region, and four polymorphisms.Biochem Biophys Res Commun. 2000 May 10;271(2):451-5. Costet P, et al. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor.J Biol Chem. 2000 Sep 8;275(36):28240-5.
ABCA7	NM019112		Kaminski WE, et al. Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene. Biochem Biophys Res Commun. 2000 Nov 30;278(3):782-9.
ABCB1 MDR1	M29423 J05168 M18754	Y-box, AP1, NF-IL6, SP1, EGR	Ueda K, et al Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene J. Biol. Chem. 1987;262, 17432-6 Madden MJ, et al. Identification of 5' and 3' sequences involved in the regulation of transcription of the human mdr1 gene in vivo. J Biol Chem. 1993; 268:8290-7.
mAbcb1a mMdr1(1a)	M60348 M34226 M90000	TATA, AP1, SP1, AP2	Raymond M, et al. Cell-specific activity of cis-acting regulatory elements in the promoter of the mouse multidrug resistance gene mdr1. Mol Cell Biol. 1990 Nov; 10(11): 6036-6040.
mAbcb1b mMdr3(1b)	M57524	TATA, AP1, SP1, AP2, Y-box	Cohen D, et al. Structural and functional analysis of the mouse mdr1b gene promoter. J. Biol Chem. 1991 Feb 5; 266(4): 2239-2244.
rAbcb1b rMdr1b	L16546	TATA, AP1, SP1, AP2, NFkB, p53	Silverman JA, et al. Characterization of the basal and carcinogen regulatory elements of the rat mdr1b promoter. Mol Carcinog. 1995 May; 13(1): 50-59. Zhou G, Kuo MT. NF-kappaB-mediated induction of mdr1b expression by insulin in rat hepatoma cells. J Biol Chem 1997 Jun 13;272(24):15174-15183 Zhou G, Kuo MT. Wild-type p53-mediated induction of rat mdr1b expression by the anticancer drug daunorubicin.J Biol Chem 1998 Jun 19;273(25):15387-15394 Ros JE, et al. Induction of Mdr1b Expression by Tumor Necrosis Factor-a in Rat Liver Cells is Independent of p53 but Requires NF-kB Signaling. Hepatology. 2001;33:1425-31
ABCB4 MDR3	Z35286	SP1	Smit JJ, et al. Characterization of the promoter region of the human MDR3 P-glycoprotein gene. Biochim Biophys Acta. 1995 Mar 14; 1261(1): 44-56
mAbcb4 mMdr2	Z35287	SP1	Yang CP, et al. Localization of sequences that influence basal and cell type-specific activity of the murine mdr2 promoter. Cell Growth Differ. 1996 Sep; 7(9): 1227-1237. Smit JJ, et al. Characterization of the promoter region of the human MDR3 P-glycoprotein gene. Biochim Biophys Acta. 1995 Mar 14; 1261(1): 44-56
rAbcb4 rMdr2	U37694	SP1	Brown PC, et al. Characterization of the rat mdr2 promoter and its regulation by the transcription factor Sp1. Nucleic Acids Res. 1996 Aug 15; 24(16): 3235-3241.
ABCB11 BSEP	AF190696	FXR/RXR	Ananthanarayanan M, et al Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J Biol Chem. 200;276(31):28857-65. Plass JR et al, Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump. Hepatology. 2002 Mar;35(3):589-96.
mAbcb11 mBsep	AF303740	FXR/RXR	Schuetz EG, et al. Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. J Biol Chem. 2001 Oct 19;276(42):39411-8.
ABCC1 MRP1	U07050	CRE,ERE,AP1, GRE,AP2,SP1	Zhu Q, et al. Cloning and sequence analysis of the promoter region of the MRP gene of HL60 cells isolated for resistance to adriamycin. Cancer Res. 1994;54:4488-4492
ABCC2 MRP2	AJ005200 AF144630 AF163577	RAR/RXR	Stockel B, et al.Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene. Eur J Biochem. 2000;267:1347-58 Tanaka T et al. The human multidrug resistance protein 2 gene: functional characterization of the 5'-flanking region and expression in hepatic cells. Hepatology. 1999;30:1507-12
rAbcc2 rMrp2	Y14995	Y-Box, GC-Box FXR/RXR CAR/RXR PXR/RXR	Kauffmann HM, Schrenk D. Sequence analysis and functional characterization of the 5'-flanking region of the rat multidrug resistance protein 2 (mrp2) gene. Biochem Biophys Res Commun 1998;245:325-331 Kast HR, et al. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem. 2002 Jan 25;277(4):2908-15.
ABCC3 MRP3	AC004590 100457-101570	N-Myc, AP1, AP2, SP1	Birren,B. et al. H. sapiens chrom. 17, clone hCIT.22_K_21 Fromm MF, et al Human MRP3 transporter: identification of the 5'-flanking region, genomic organization and alternative splice variants. Biochim Biophys Acta 1999;1415(2):369-374 Stockel B, et al.Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene. Eur J Biochem. 2000;267:1347-58
ABCD2	AF302501	SP1, AP2	Pujol,A., et al. Characterization of the Adrenoleukodystrophy-related (ALDR, ABCD2) gene promoter: Inductibility by retinoic acid and forskolin. Genomics 2000 Nov 15;70(1):131-9
ABCG1	AJ289137	SP1, SREBP	Langmann T, et al. Genomic organization and characterization of the promoter of the human ATP-binding cassette transporter-G1 (ABCG1) gene(1).Biochim Biophys Acta. 2000 Nov 15;1494(1-2):175-80
ABCG2	AF356347	SP1	Bailey-Dell KJ, et al. Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene.Biochim Biophys Acta. 2001 Sep 21;1520(3):234-41.
ABCG5/G8	NM 022436 NM 022437	LXRa/b	Repa JJ, et al Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta J Biol Chem. 2002 May 24;277(21):18793-800