reprints: michael.muller@wur.nl
Selected Publications Ishikawa T, Müller M, Klünemann C, Schaub T, Keppler D. ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membranes. J Biol. Chem. 265: 19279-19286, 1990 Müller M, Ishikawa T, Berger U, Klünemann C, Lucka L , Schreyer A, Kannicht C, Reutter W, Kurz G, Keppler D. ATP-dependent transport of taurocholate across the hepatocyte canalicular membrane mediated by a 110-kDa glycoprotein binding ATP and bile salt. J Biol. Chem. 266: 18920-18926, 1991 Böhme M, Müller M, Leier I , Jedlitschky G , Keppler D. Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver. Gastroenterology 107: 255-265, 1994 Müller M, Mayer R , Hero U, Keppler D. ATP-dependent transport of amphiphilic cations across the hepatocyte canalicular membrane mediated by mdr1 p-glycoprotein. FEBS. Lett. 343: 168-172, 1994 Müller M, Meijer C, Zaman GJR, Borst P, Scheper R J, Mulder NH, de Vries EGE, Jansen PLM. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc. Natl. Acad. Sci. USA. 91: 13033-13037, 1994 de Vries EGE, Müller M, Meijer C, Jansen PLM, Mulder NH. Role of the glutathione S-conjugate pump in cisplatin resistance. J Nat. Cancer Inst. 87: 537-538, 1995 Dijkstra M, In 't Veld G, Vandenberg GJ, Müller M, Kuipers F, Vonk RJ. Adenosine triphosphate-dependent copper transport in isolated rat liver plasma membranes. J Clin. Invest. 95: 412-416, 1995. Bossuyt X, Müller M, Hagenbuch B, Meier PJ. Polyspecific steroid and drug clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther 276: 891-896, 1996. Bossuyt X, Müller M, Meier PJ. Multispecific amphipathic substrate transport by an organic anion transporter of human liver. J Hepatol. 25:733-738, 1996. Müller M, de Vries EGE, Jansen PLM. Role of the multidrug resistance protein (MRP) in glutathione S-conjugate transport in mammalian cells. J Hepatol. 24: 100-108, 1996. Müller M, Roelofsen H, Jansen PLM. Secretion of organic anions by hepatocytes: Involvement of homologues of the Multidrug Resistance Protein. Sem. Liver Dis. 16: 211-220, 1996. Roelofsen H, TA Vos, IJ Schippers, F Kuipers, H Koning, H Moshage, PLM Jansen, M Müller. Increased levels of the multidrug resistance protein in lateral membranes of proliferating hepatocyte-derived cells. Gastroenterology 112:511-521, 1997. Asschert J, de Vries E, van der Kolk D, Müller M, Vellenga E. The combined effects of IL-3 and PSC 833 on daunorubicin- and mitoxantrone cytotoxicity in two growth factor-dependent leukemic cell lines. Leukemia 11:680-686, 1997 Müller M, Jansen PLM Molecular aspects of hepatobiliary transport. Am J Physiol 272:G1285-G1303, 1997 Meijer DKF, Smit JW, Müller M. Hepatobiliary elimination of cationic drugs: the role of P-glycoproteins and other ATP-dependent transporters. Adv Drug Delivery Rev 25:159-200, 1997 Koopen NR, Wolters H, Müller M, Schippers IJ, Havinga R, Roelofsen H, Vonk R, Stieger B, Meier PJ, Kuipers F: Hepatic bile salt flux does not modulate level and activity of the sinusoidal Na+-taurocholate cotransporter (ntcp) in rats. J Hepatol 1997; 27:699-706 Bakker M, Renes J, Groenhuijzen A, Visser P, Timmer-Bosscha H, Müller M, Groen HJ, Smit EF, de Vries EG. Mechanisms for high methoxymorpholino doxorubicin cytotoxicity in doxorubicin-resistant tumor cell lines. Int J Cancer 1997;73:362-366 Schippers IJ, Moshage H, Roelofsen H, Müller M, Heymans HS, Ruiters M, Kuipers F. Immortalized human hepatocytes as a tool for the study of hepatocytic (de-)differentiation. Cell Biol Toxicol 1997; 13:375-386 Koopen NR, Wolters H, Havinga R, Vonk RJ, Jansen PLM, Müller M, Kuipers F. Impaired activity of the bile canalicular organic anion transporter (mrp2/cmoat) is not the main cause of ethinylestradiol-induced cholestasis in the rat. Hepatology 1998; 27: 537-545 Müller M, Jansen PLM. The secretory function of the liver: New insights in hepatobiliary transport. J Hepatol 1998; 28:344-354 Smit JW, Schinkel AH, Müller M, Weert B, Meijer DKF. Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption. Hepatology 1998;27:1056-1063 van Lyun M, Müller M, Renes J, Meijer C, Scheper RJ, Nienhuis EF, Mulder NH, Jansen PLM, de Vries EGE. Transport of glutathione conjugates into secretory vesicles is mediated by the multidrug-resistance protein 1. Int J Cancer. 1998; 76: 55-62 Jansen PLM, Müller M. Progressive familial intrahepatic cholestasis types 1, 2, and 3. Gut 1998; 42: 766-767 van der Kolk DM., de Vries EGE, Koning HJ, van den Berg E, Müller M, Vellenga E. Activity and expression of the multidrug resistance proteins MRP1 and MRP2 in acute myleoid leukemia cells, tumor cell lines, and nomal hematopoietic CD34+ peripheral blood cells. Clin.Canc.Res. 1998; 4:1727-1736 Koopen, NR, Müller M, Vonk, RJ, Zimniak P, Kuipers F. Molecular mechanisms of cholestasis: causes and consequences of impaired bile formation. Biochim. Biophys. Acta. 1998; 1408, 1-17 Vos TA, Hooiveld GJEJ, Koning H, Childs S, Meijer DKF, Moshage H, Jansen PLM, Müller M. Up-regulation of the multidrug resistance genes, mrp1 and mdr1b, and down-regulation of the organic anion transporter, mrp2, and the bile salt transporter, spgp, in endotoxemic rat liver. Hepatology 1998 Dec;28(6):1637-1644 Jansen PLM, Müller M. Early events in sepsis-associated cholestasis. Gastroenterology 1999;116:486-488 Renes J, de Vries EGE, Nienhuis, EF, Jansen, PLM, Müller M. ATP- and glutathione dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1. Brit. J. Pharmacol. 1999; 126:681-688 Vellenga E, Tuyt L, Wierenga B-J, Koopmans S, Müller M, Dokter W. Interleukin-6 production by activated human monocytic cells is enhanced by the leukotriene D4 receptor antagonist MK-571. Brit. J. Pharmacol. 1999; 127:441- 448 Roelofsen H, Hooiveld GJEJ, Koning H, Havinga R, Jansen PLM, Müller M. Glutathione S-conjugate transport in hepatocytes entering the cell cycle is preserved by a switch in expression from the apical MRP2 to the basolateral MRP1 transporting protein. J. Cell Science 1999;112: 1395-1404 Vos TA, Ros J, Havinga R, Moshage H, Kuipers F, Jansen PLM, Müller M. Regulation of hepatic transport systems involved in bile secretion during liver regeneration in rats. Hepatology 1999;29:1833-1839 Meerman L, Koopen NR, Bloks V, van Goor H, Havinga R, Wolthers BG, Kramer W, Stengelin S, Müller M, Kuipers F, Jansen PLM. Biliary fibrosis associated with altered bile composition in a mouse model of erythropoetic protoporphyria. Gastroenterology 1999;117:696-705 Hooiveld GJEJ, Vos TA, Scheffer GL, van Goor H, Koning HJ, Bloks V, Loot AE, Meijer DKF, Jansen PLM, Kuipers F, Müller M. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) induce hepatic expression of the phospholipid translocase mdr2 P-glycoprotein in rats. Gastroenterology 1999;117:678-687 von Montfoort JE, Hagenbuch B, Fattinger K, Müller M, Groothuis GMM, Meijer DKF, Meier PJ. Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther 1999; 291:147-152 van der Kolk DM, Vellenga E, Müller M, de Vries EG. Multidrug resistance protein MRP1, glutathione, and related enzymes. Their importance in acute myeloid leukemia. Adv Exp Med Biol 1999;457:187-98 Meijer DK, Smit JW, Hooiveld GJ, van Montfoort JE, Jansen PL, Müller M. The molecular basis for hepatobiliary transport of organic cations and organic anions. Pharm Biotechnol 1999;12:89-157 Mills CO, Milkiewicz P, Müller M, Roma MG, Havinga R, Coleman R, Kuipers F, Jansen PLM, Elias E. Different pathways of canalicular secretion of sulfated and non-sulfated fluorescent bile acids: a study in isolated hepatocyte couplets. and TR- rats. J Hepatol. 1999; 31:678-684 Schaefer M, Roelofsen H, Wolters H, Hofmann WJ, Müller M, Kuipers F, Stremmel W, Vonk RJ. Localization of the Wilson's Disease protein in human liver Gastroenterology 1999 117:1380-1385 Jansen PLM, Strautnieks SS, Jacquemin E, Hadchouel M, Sokal EM, Hooiveld GJEJ, Koning JH, de Jager-Krikken A, Kuipers F, Stellaard F, Bijleveld CMA, Gouw ASH, van Goor H, Thompson RJ, Müller M. Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis. Gastroenterology 1999; 117:1370-1379 Jansen PLM, Müller M. Genetic cholestasis: Lessons from the molecular physiology of bile formation. Can J Gastroenterol 2000; 14(3):233-238 van der Kolk DM, Vellenga E, Van der Veen AY, Noordhoek L, Timmer-Bosscha H, Ossenkoppele GJ, Raymakers RA, Müller M, van den Berg E, de Vries EGE. Deletion of the multidrug resistance protein MRP1 gene in acute myeloid leukemia: the impact on MRP activity. Blood 2000; 95 (11): 3514-3519 van Veen HW, Margolles A, Müller M, Higgins CF, Konings WN. The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism. EMBO J. 2000; 19:2503-2514 Kok JW, Veldman RJ, Klappe K, Filipeanu CM, Müller M. Differential expression of sphingolipids in MRP1 overexpressing HT29 cells. Int.J.Cancer. 2000; 87, 172-178 Jansen PLM, Müller M. The molecular genetics of familial intrahepatic cholestasis. Gut 2000; 47: 1-5 Gupta S, Stravitz RT, Pandak WM, Müller M, Vlahcevic ZR, Hylemon PB. Regulation of multidrug resistance 2 P-glycoprotein expression by bile salts in rats and in primary cultures of rat hepatocytes. Hepatology 2000; 32:341-347 Renes J, de Vries EGE, Hooiveld GJEJ, Krikken I, Jansen PLM, Müller M. The multidrug resistance protein MRP1 protects against the toxicity of the major lipid peroxidation product 4-hydroxynonenal. Biochem. J. 2000; 350: 555-561 Müller M. The transcriptional control of hepatocanalicular transporter gene expression. Sem.Liver Dis. 2000; 20: 323-335 Hooiveld GJEJ, van Montfoort JE, Meijer DKF, Müller M. Function and regulation of ATP-binding cassette transport proteins involved in hepatobiliary transport. Eur.J.Pharm.Sci. 2000; 12:13-30 Erratum Renes J, de Vries EGE, Jansen PLM, Müller M. The (patho)physiological functions of the MRP family. Drug Resistance Updates 2000; 3:289-302 Van Den Heuvel MC, Sloof MJH, Visser L, Müller M, De Jong KP, Poppema S, Gouw ASH. Expression of anti-OV6 antibody and anti-N-CAM antibody along the biliary line of normal and diseased human livers. Hepatology. 2001;33:1387-93 Ros JE, Schuetz JD, Geuken M, Streetz K, Moshage H, Kuipers F, Manns MP, Jansen PLM, Trautwein C, Müller M. Induction of Mdr1b Expression by Tumor Necrosis Factor-a in Rat Liver Cells is Independent of p53 but Requires NF-kB Signaling. Hepatology. 2001;33:1425-31 van Montfoort JE, Müller M, Groothuis GM, Meijer DK, Koepsell H, Meier PJ. Comparison of "Type I" and "Type II" organic cation transport by organic cation transporters (OCTs) and organic anion transporting polypeptides (OATPs). J Pharmacol Exp Ther. 2001;298:110-115 van der Kolk DM, de Vries EG, Noordhoek L, van den Berg E, van der Pol MA, Müller M, Vellenga E. Activity and expression of the multidrug resistance proteins P-glycoprotein, MRP1, MRP2, MRP3 and MRP5 in de novo and relapsed acute myeloid leukemia. Leukemia 2001;15:1544-53 Jansen PLM, Müller M, Sturm E. Genes and cholestasis. Hepatology. 2001;34:1067-74 Plass JRM, Mol O, Heegsma J, Geuken M, Faber KN, Jansen PLM, Müller M. Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump. Hepatology 2002;35:589-96 Van der Kolk DM, Vellenga E, Scheffer GL, Müller M, Bates SE, Scheper RJ, de Vries EGE. Expression and activity of breast cancer resistance proetin (BCRP) in de novo and relapsed acute myeloid leukemia. Blood. 2002;99:3763-3770 Scheffer GL, Pijnenborg AC, Smit EF, Müller M, Postma DS, Timens W, Van Der Valk P, De Vries EG, Scheper RJ. Multidrug resistance related molecules in human and murine lung. J Clin Pathol. 2002;55:332-339 Van der Kolk DM, de Vries EGE, Müller M, Vellenga E. The role of drug efflux pumps in acute myeloid leukemia. Leukemia and Lymphoma 2002; 43:685-701 W. M. van Waarde, H. J. Verkade, H. Wolters, R. Havinga, J. Baller, V. Bloks, M. Müller, P. J. J. Sauer, F. Kuipers. Differential effects of streptozotocin-induced diabetes on expression of hepatic ABC-transporters in rats. Gastroenterology 2002;122:1842-52 Hooiveld GJEJ, Heegsma J, van Montfoort JE, Jansen PLM, Meijer DKF, Müller M. Stereoselective transport of hydrophilic quaternary drugs by human MDR1 and rat Mdr1b P-glycoproteins. Brit J Pharmacology 2002;135:1685-1694 Cool RH, Veenstra MK, Van Klompenburg W, Heyne RI, Müller M, De Vries EG, Van Veen HW, Konings WN. S-Decyl-glutathione nonspecifically stimulates the ATPase activity of the nucleotide-binding domains of the human multidrug resistance-associated protein, MRP1 (ABCC1). Eur J Biochem. 2002;269:3470-3478 Faber KN, Müller M, Jansen PLM. Drug transport proteins in the liver. Adv Drug Deliv Rev 2003;55:107-24 Ros JE, Roskams TAD, Geuken M, Havinga R, Splinter PL, Petersen BE, LaRusso NF, Kuipers F, Faber KN, Müller M, Jansen PLM. ATP binding cassette transporter gene expression in rat liver progenitor cells. Gut 2003;52;7:1060-1067 Müller M, Kersten S. Nutrigenomics: Goals and Perspectives. Nature Reviews Genetics 2003;4:315 -322 Plass JR, Mol O, Heegsma J, Geuken M, de Bruin J, Elling G, Müller M, Faber KN, Jansen PL. A progressive familial intrahepatic cholestasis type 2 mutation causes an unstable, temperature-sensitive bile salt export pump. J Hepatol. 2004;40:24-30 Mandard S, Müller M, Kersten S. Peroxisome proliferator-activated receptor a target genes. CMLS, Cell. Mol. Life Sci. 2004;61:393-416 Stienstra R, Lichtenauer-Kaligis E, Müller M. Stress- (and diet-) related regulation of hepatic nuclear receptors and its relevance for ABC-transporter functions Drug Metabolism Reviews 2004:36:391-406 Patsouris D, Mandard S, Voshol PJ, Escher P, Tan NS, Havekes LM, Koenig W, Marz W, Tafuri S, Wahli W, Müller M, Kersten S. PPARalpha governs glycerol metabolism J Clin Invest. 2004 Jul;114(1):94-103 Mandard S, Zandbergen F, Tan NS, Escher P, Patsouris D, Koenig W, Kleemann R, Bakker A, Veenman F, Wahli W, Müller M, Kersten S. The direct PPAR target FIAF/PGAR/ANGPTL4 is present in blood plasma as a truncated protein that is increased by fenofibrate treatment. J Biol Chem. 2004;279(33):34411-20 Patsouris D, Müller M, Kersten S. Peroxisome proliferator activated receptor ligands for the treatment of insulin resistance. Curr Opin Investig Drugs. 2004;5(10):1045-50 Klein C, Wüstefeld T, Assmus U, Roskams T, Rose-John S, Müller M, Manns MP, Ernst E, Trautwein C The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury. J. Clin. Invest. 115:860-869 (2005) Zandbergen F, Mandard S, Escher P, Tan NS, Patsouris D, Jatkoe T, Rojas-Caro S, Madore S, Wahli W, Tafuri S, Müller M, Kersten S. The G0/G1 switch gene 2 is a novel PPAR target gene. Biochem J. 2005;392:313-24. Corthesy-Theulaz I, den Dunnen JT, Ferre P, Geurts JM, Müller M, van Belzen N, van Ommen B. Nutrigenomics: The Impact of Biomics Technology on Nutrition Research. Ann Nutr Metab. 2005;49:355-365 Kaput J, Ordovas JM, Ferguson L, van Ommen B, Rodriguez RL, Allen L, Ames BN, Dawson K, German B, Krauss R, Malyj W, Archer MC, Barnes S, Bartholomew A, Birk R, van Bladeren P, Bradford KJ, Brown KH, Caetano R, Castle D, Chadwick R, Clarke S, Clement K, Cooney CA, Corella D, Manica da Cruz IB, Daniel H, Duster T, E Ebbesson SO, Elliott R, Fairweather-Tait S, Felton J, Fenech M, Finley JW, Fogg-Johnson N, Gill-Garrison R, Gibney MJ, Gillies PJ, Gustafsson JA, Hartman Iv JL, He L, Hwang JK, Jais JP, Jang Y, Joost H, Junien C, Kanter M, Kibbe WA, Koletzko B, Korf BR, Kornman K, Krempin DW, Langin D, Lauren DR, Ho Lee J, Leveille GA, Lin SJ, Mathers J, Mayne M, McNabb W, Milner JA, Morgan P, Müller M, Nikolsky Y, van der Ouderaa F, Park T, Pensel N, Perez-Jimenez F, Poutanen K, Roberts M, Saris WH, Schuster G, Shelling AN, Simopoulos AP, Southon S, Tai ES, Towne B, Trayhurn P, Uauy R, Visek WJ, Warden C, Weiss R, Wiencke J, Winkler J, Wolff GL, Zhao-Wilson X, Zucker JD. The case for strategic international alliances to harness nutritional genomics for public and personal healthdagger. Br J Nutr. 2005;94:623-632. Mandard S, Zandbergen F, van Straten E, Wahli W, Kuipers F, Müller M, Kersten S. The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. J Biol Chem. 2006 Jan 13;281(2):934-44 Patsouris D, Reddy JK, Müller M, Kersten S. PPAR{alpha} mediates the effects of high fat diet on hepatic gene expression. Endocrinology. 2006 Mar;147:1508-16 Afman L, Müller M. Nutrigenomics: from molecular nutrition to prevention of disease. J Am Diet Assoc. 2006;106:569-76 Murphy EF, Jewell C, Hooiveld GJ, Müller M, Cashman KD. Conjugated linoleic acid enhances transepithelial calcium transport in human intestinal-like Caco-2 cells: an insight into molecular changes. Prostaglandins Leukot Essent Fatty Acids. 2006;74:295-301 Krapels IP, Vermeij-Keers C, Müller M, de Klein A, Steegers-Theunissen RP. Nutrition and genes in the development of orofacial clefting. Nutr Rev. 2006;64:280-8
2007
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Mandard S, Stienstra R, Escher P, Tan NS, Kim I, Gonzalez FJ, Wahli W,
Desvergne B, Müller M, Kersten S Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors. Cell Mol Life Sci. 2007 May;64(9):1145-57 |
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Bunger M, van den Bosch HM, van der Meijde J, Kersten S,
Hooiveld GJ, Müller M Genome-wide analysis of PPAR{alpha} activation in murine small intestine Physiol Genomics. 2007 Jul 18;30(2):192-204 |
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Stienstra R, Mandard S, Patsouris D, Maass C, Kersten S,
Müller M PPAR{alpha} protects against obesity-induced hepatic inflammation Endocrinology. 2007 Jun;148(6):2753-63 |
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Busstra MC, Hartog R, Kersten S, Müller M Design guidelines for the development of digital nutrigenomics learning material for heterogeneous target groups Adv Physiol Educ. 2007 Mar;31(1):67-75. |
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Joost HG, Gibney MJ, Cashman KD, Gorman U, Hesketh JE, Müller M, van Ommen B, Williams CM, Mathers JC Personalised nutrition: status and perspectives Br J Nutr. 2007 Jul;98(1):26-31 |
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Stienstra R, Duval C, Müller M, Kersten S PPARs, Obesity, and Inflammation PPAR Res. 2006 Nov 23;2007:95974 |
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Stienstra R, Mandard S, Tan NS, Wahli W, Trautwein C,
Richardson TA, Lichtenauer-Kaligis E, Kersten S, Müller
M The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver J Hepatol. 2007 May;46(5):869-77 |
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Ricketts ML, Boekschoten MV, Kreeft AJ, Hooiveld GJ, Moen CJ, Müller M, Frants RR, Kasanmoentalib S, Post SM, Princen HM, Porter JG, Katan MB,
Hofker MH, Moore DD The Cholesterol-Raising Factor from Coffee Beans, Cafestol, as an Agonist Ligand for the Farnesoid and Pregnane X Receptors. Mol Endocrinol. 2007 Jul;21(7):1603-16. |
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Duval C, Müller M, Kersten S PPARalpha and dyslipidemia. Biochim Biophys Acta. 2007 Aug;1771(8):961-71 |
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Rakhshandehroo
M, Sanderson LM, Matilainen M,
Stienstra R, Carlberg C, de Groot PJ, Müller M, Kersten S. Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling, PPAR Research, vol. 2007, Article ID 26839, 13 pages |
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Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting BMC Genomics 2007, 8:267 |
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Bünger M, Hooiveld GJ, Kersten S, Müller M Exploration of PPAR functions by microarray technology-A paradigm for nutrigenomics. Biochim Biophys Acta. 2007 Aug;1771(8):1046-64. |
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Murphy EF, Hooiveld GJ, Müller M, Calogero RA, Cashman KD
Conjugated linoleic acid alters global gene expression in human intestinal-like Caco-2 cells in an isomer-specific manner. |
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Bouwens M, Afman LA, Müller M
Fasting induces changes in peripheral blood mononuclear cell gene expression profiles related to increases in fatty acid {beta}-oxidation: functional role of peroxisome proliferator activated receptor {alpha} in human peripheral blood mononuclear cells. |
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Lichtenstein L, Berbée JF, van Dijk SJ, van Dijk KW, Bensadoun A,
Kema IP, Voshol PJ, Müller M, Rensen PC, Kersten S
Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake. |
| 1 |
de Wilde J, Mohren R, van den Berg S, Boekschoten M, Willems-Van Dijk K,
De Groot P, Müller M, Mariman EC, Smit E
Short-term high fat-feeding results in morphological and metabolic
adaptations in the skeletal muscle of C57BL/6J mice.
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| 2 |
Sanderson
LM de Groot PJ,
Hooiveld GJEJ, Koppen A, Kalkhoven E, Müller M, Kersten S |
| 3 |
van den Bosch HM, De Wit NJ, Hooiveld GJ, Vermeulen H, van der Veen JN,
Houten SM, Kuipers F, Müller
M, van der Meer R
A cholesterol free, high-fat diet suppresses gene expression of
cholesterol transporters in murine small intestine.
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| 4 |
de Wit
NJ, Bosch-Vermeulen H, de Groot PJ, Hooiveld GJE, Grootte Bromhaar MM,
Jansen J, Müller M, van der Meer R The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice BMC Medical Genomics 2008, 1:14 |
| 5 |
de Vogel-van den Bosch HM, Bünger M, de Groot PJ, Bosch-Vermeulen H,
Hooiveld GJ, Müller M PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression. BMC Genomics 2008, 9:231 |
| 6 |
Bouwens M, Afman LA, Müller M |
| 7 |
Herrema H, Derks TGJ, van Dijk
TH, Bloks VW, Gerding A, Havinga R, Tietge UJF,
Müller M, Smit PA, Kuipers F, Reijngoud DJ Disturbed Hepatic Carbohydrate Management During High Metabolic Demand in Medium-Chain Acyl-CoA Dehydrogenase (MCAD)-Deficient Mice Hepatology 2008 Jun;47(6):1894-904 |
| 8 |
The NuGO proof of principle study package: a collaborative research
effort of the European Nutrigenomics Organisation. |
| 9 |
NuGO contributions to GenePattern. |
| 10 |
The challenges for molecular nutrition research 2: quantification of the
nutritional phenotype. |
| 11 |
PPARgamma activation promotes infiltration of alternatively
activated macrophages into adipose tissue
Stienstra R, Duval C, Keshtkar S, van der Laak J, Kersten S, Müller M. |
2009 (Impactfactor > 5 & > 10)
| 1 |
Murphy EF, Hooiveld GJ, Müller M, Calogero RA, Cashman KD. |
| 2 |
Giebeler A, Boekschoten MV, Klein C,
Borowiak M, Birchmeier C, Gassler N,
Wasmuth HE, Müller M, Trautwein C,
Streetz KL. c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile-duct-ligation in mice Gastroenterology. 2009; 137: 297-308 |
| 3 |
Vaes BL, Lute C, Blom HJ, Bravenboer N, de Vries TJ, Everts V,
Dhonukshe-Rutten RA, Müller M, de Groot LC, Steegenga WT. Vitamin B(12) Deficiency Stimulates Osteoclastogenesis via Increased Homocysteine and Methylmalonic Acid. Calcif Tissue Int. 2009 Apr 12. |
| 4 |
Kersten S, Lichtenstein L, Steenbergen E, Mudde K, Hendriks HF,
Hesselink MK, Schrauwen P, Müller M. |
| 5 |
Bouwens M, van de Rest O, Dellschaft N, Bromhaar MG, de Groot LC,
Geleijnse JM, Müller M, Afman LA. Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells. Am J Clin Nutr. 2009 Aug; 90:415-24 |
| 6 |
Kersten S, Müller M. Dropping liver fat droplets. Hepatology 2009 Aug;50(2):645-7 |
| 7 |
Radonjic M, de Haan JR, van Erk MJ, van Dijk KW, van den Berg SAA, de
Groot PJ, Müller M, van Ommen B Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program. PLoS One. 2009 Aug 14;4(8):e6646 |
| 8 |
Bioactive compounds: Definition and assessment of activity. Biesalski HK, Dragsted LO, Elmadfa I, Grossklaus R, Müller M, Schrenk D, Walter P, Weber P Nutrition. 2009 Aug 18 |
| 9 |
Rakhshandehroo M, Hooiveld G, Müller M, Kersten S. Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human Plos ONE 2009 Aug 27;4(8):e6796. |
| 10 |
Vaes BL, Lute C, van der Woning SP, Piek E, Vermeer J, Blom HJ, Mathers
JC, Müller M, de Groot LC, Steegenga WT Inhibition of methylation decreases osteoblast differentiation via a non-dna methylation dependent mechanism. Bone. 2009 Oct 5. |
| 11 |
van Dijk SJ, Feskens EFM, Bos MB, Hoelen DWM, Heijligenberg R,
Grootte-Bromhaar M, de Vries JHM, Müller M, Afman LA A saturated fatty acid rich diet induces an ‘obese-linked pro-inflammatory gene expression profile’ in adipose tissue of subjects at risk for metabolic syndrome. Am J Clin Nutr. 2009 in press |
| 12 |
Sanderson L, Degenhardt T, Desvergne B, Müller M, Kersten S PPARβ/δ but not PPARα serves as plasma free fatty acid sensor in liver Mol. Cell. Biol. 2009 in press |
| 13 |
Stienstra R, Saudale F, Duval C, Keshtkar S, Groener JEM, van Rooijen N,
Staels B, Kersten S, Müller M Kupffer cells promote hepatic steatosis via IL-1β dependent suppression of PPARalpha activity Hepatology 2009 in press |
| 14 |
Bile salt sequestration induces hepatic de novo lipogenesis via FXR and
LXR-controlled metbolic pathways in mice Hepatology 2009 in press |
| 15 |
The potential influence of genetic variants in genes along bile acid and
bile metabolic pathway on blood cholesterol levels in the population Atherosclerosis 2009 in press |
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Book chapter
Afman L and Müller M
Transcriptomics applications in human nutrigenomics studies
pp 15-20; In “Design of human nutrigenomics studies” edited by: Siân Astley and
Linda Penn 2009, 104 pages
Wageningen Academic Publishers ISBN: 978-90-8686-094-4
reprints: michael.muller@wur.nl