Human ABC-Transporters

I have to apologize, but somehow the page disappeared from my site.
I found a version back in the web archive but it is not up-to-date, I will do my best to update it again! Be patient, will keep you informed.

ABC1 (subfamily A)
	Name/Symbol	Properties	Links	Phenotype	Access	Animals	Tissue/Regulation	Function/Substrates
1	ABC1 TGD HDLDT1 CERP ABCA1	9q22-q31 52 Exons SeqView 6.9 kB 2261 AA 254284 Da		Mutations in this gene have been associated with Tangier Disease T1 and familial high-density lipoprotein deficiency. also Tangier	NM005502 LocusLink Swiss-Prot GeneCard	Mouse Rat	Many tissues	ABCA1 is a major regulator of cellular cholesterol and phospholipid homeostasis. It mediates e.g. the efflux of phospholipids (PS) and cholesterol from macrophages to apoA-I, reversing foam cell formation. Likely not involved in hepatic cholesterol secrection and intestinal apical cholesterol transport (→ ABCG5/G8).
							LXRa
2	ABCA2 ABCA2	9q34 48 Exons SeqView 8 kB 2436 AA			NM001606 LocusLink Swiss-Prot GeneCard	Mouse Rat	Brain Kidney Lung Heart
3	ABCA3 ABC-C ABCA3	16p13.3 SeqView 6.5 kB 1704 AA			NM001089 LocusLink Swiss-Prot GeneCard	Mouse Rat	Lung + other tissues
4	ABCR RP19, ABC10 FFM, STGD1 STGD, RIM, RMP ABCA4	1p22 50 Exons. SeqView 7.3 kB 2273 AA		Mutations in this gene are found in patients diagnosed with Stargardt disease-1 and are associated with Age-related Mac.dyst.2 Ret. pigmentosa Retina Mut. Db	NM000350 LocusLink Swiss-Prot GeneCard	Mouse Rat Bos taurus	Retina, photoreceptor cells	This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane.
5	ABCA5 ABCA5	17q21-q24 6.5 kB 1642 AA			NM018672 LocusLink Swiss-Prot GeneCard	Mouse Rat	Muscle Heart Testes upregulated in cultured hepatocytes
6	ABCA6 ABCA6	17q21 5.3 kB 1617 AA			NM080284 LocusLink Swiss-Prot GeneCard	Mouse Rat	Liver
7	ABCA7 ABCX ABCA7	19p13.3 SeqView 6.6 kB 2146 AA			NM019112 LocusLink Swiss-Prot GeneCard	Mouse Rat	Peripheral leukocytes, Thymus, Spleen, Bone marrow	This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. Alternative splicing of this gene results in two transcript variants.
8	ABCA8 ABCA8	17q24 5.7 kB 1581 AA			NM007168 LocusLink Swiss-Prot GeneCard	Mouse Rat	Ovary	This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known.
9	ABCA9 ABCA9	17q24 6 kB 1624 AA			NM080283 LocusLink Swiss-Prot GeneCard	Mouse Rat	Heart	This gene is clustered among 4 other ABC1 family members on 17q24 and may play a role in monocyte differentiation and macrophage lipid homeostasis.
10	ABCA10 ABCA10	17q24 6.18 kB 1543 AA			LocusLink Swiss-Prot GeneCard	Mouse Rat	Muscle Heart also in monocytes and M-CSF differentiated macrophages	This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. ABCA10 expression is suppressed by cholesterol import into macrophages, indicating that it is a cholesterol-responsive gene.
11	ABCA12 ABCA12	2q35 7 kB 2595 AA			NM015657 LocusLink Swiss-Prot GeneCard	Mouse Rat	Stomach
12	ABCA13 ABCA13	7p11-q11 gene 450 kB 62 exons 5058 AA!!			NM152701 LocusLink Swiss-Prot GeneCard	Mouse Rat	Major transcript shows highest expression in human trachea, testis, and bone marrow	The predicted ABCA13 protein consists of 5,058 amino acid residues making it the largest ABC protein described to date. ABCA13 contains a hydrophobic, predicted transmembrane segment at the N-terminus, followed by a large hydrophilic region.
MDR/TAP (subfamily B)
	Name/Symbol	Properties	Links	Phenotype	Access	Animal	Tissue/Regulation	Function/Substrates
1	PGY1 MDR1 P-GP GP170 ABCB1	7q21 28 exons 4.5 1280 AA			NM000927 LocusLink Swiss-Prot GeneCard	Mouse Abcb1a Rat Abcb1a Mouse Abcb1b Rat Abcb1b	Many tissues (especially those with barrier functions such as liver, BBB, kidney, intestine, placenta) apical membranes	The protein (also called P-glycoprotein) is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs.

2	TAP1 PSF1 RING4 ABC17 APT1 D6S114E ABCB2	6p21.3 11 exons 2.5 808 AA		Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.	NM000593 LocusLink Swiss-Prot GeneCard	Mouse Rat	Most cells ER	The protein is a half-abc transporter functioning as peptide transporter involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble.
3	TAP2 PSF2 RING11 D6S217E ABC18 ABCB3	6p21.3 11 ex. 2.8 653		Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.	NM000544 LocusLink Swiss-Prot GeneCard	Mouse Rat	Most cells ER	The protein is a half-abc transporter functioning as peptide transporter involved in antigen presentation. It forms a heterodimer with TAP1/ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.
4	PGY3 MDR2/3 MDR3 PFIC-3 ABC21 ABCB4	7q21 28 exons 4.5 1279		PFIC-3 ICP	NM000443 LocusLink Swiss-Prot GeneCard	Mouse Rat	Hepatocyte apical membranes	Most likely involved in biliary phosphatidylcholine secretion from hepatocytes in a bile salt-dependent manner. Biliary PC is necessary to keep the bile "non-toxic".
							PPARa?, FXR?
5	ABCB5 ABCB5	7p14 7.5			U66692 AC002486 XM291215 LocusLink Swiss-Prot Genecard	Mouse Rat	Ubiquitous
6	ABCB6 ABC14 UMAT MTABC3 ABCB6	2q33-q36 19 ex. 3.5 842		This gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function.	NM 005689 LocusLink Swiss-Prot GeneCard	Mouse Rat	Mitochondria	This half-transporter likely plays a role in mitochondrial function and possibly transports iron.
7	ABC7 ATM1P ASAT ABCB7	Xq13.1-q13.3 2.4 752		Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.	NM004299 LocusLink Swiss-Prot GeneCard	Mouse Rat	Mitochondria	This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis.
8	M-ABC1 ABCB8	7q35-q36 2.4 718			NM 007188 LocusLink Swiss-Prot GeneCard	Mouse Rat	Mitochondria	The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes.
9	ABCB9 TAPL ABCB9	12q24 3.5 kB 723 AA 766 AA			NM 019624 NM019625 LocusLink Swiss-Prot GeneCard	Mouse Rat	Heart Brain Lysosomes	The function of this half-transporter has not yet been determined; however, this protein may play a role in lysosomes. Alternative splicing of this gene results in two known products which are likely to have different substrate specifications.
10	ABCB10 M-ABC2 MTABC2 ABCB10	1q42 (Pseudogene on 15q13-14) 4.1 kB 738 AA			NM 012089 LocusLink Swiss-Prot GeneCard	Mouse Rat	Mitochondria	Peptides?
11	BSEP SPGP PFIC2 PGY4 ABC16 ABCB11	2q24 5.4 kB 1321 AA		Mutations in this gene cause a form of progressive familial intrahepatic cholestases (PFIC-2) which are a group of inherited disorders with severe cholestatic liver disease from early infancy.	NM 003742 NP 003733 LocusLink Swiss-Prot GeneCard	Mouse Rat	Hepatocytes apical membranes	BSEP is the major canalicular bile salt export pump in man responsible for active transport of bile salts across the hepatocyte canalicular membrane into bile. It represents the molecular basis of the bile-salt-dependent bile flow. BSEP activity is necessary for PC secretion via PGY3/ABCB4.
							FXR
CFTR/MRP (subfamily C)
	Name/Symbol	Properties	Links	Phenotype	Access	Rodent	Tissue/Regulation	Function/Substrates
1	MRP1 MRP, ABCC, GS-X, ABC29 ABCC1	16p13.1 31 exons 6.5 kB 1531 AA		This transporter is involved in multi-drug resistance.	NM 004996 NP_004987 LocusLink Swiss-Prot GeneCard	Mouse Rat	Many tissues Lung Testes PBMC lateral membranes	MRP1 functions as a multispecific organic anion transporter, with (oxidized) glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. It also transports drugs and other hydrophobic compounds in presence of glutathione.

2	MRP2 CMOAT ABCC2	10q24 32 exons 5.5 kB 1545 AA		Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.	NM 000392 NP_000383 LocusLink Swiss-Prot GeneCard	Mouse Rat	Liver Intestine Kidney apical membranes	MRP2 is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport of mainly anionic conjugates with glutathione, with sulfate or with glucuronosyl e.g. glucuronosyl bilirubin. Other substrates include anticancer drugs such as vinblastine (similar specificity as MRP1/ABCC1); appears to contribute to drug resistance.
							FXR?
3	MRP3 ABCC3	17q21.3 6.5 kB 1527 AA			NM 003786 LocusLink Swiss-Prot GeneCard	Mouse Rat	Intestine Kidney up-regulated in cholestatic livers lateral membranes	The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions including bile salts.
							LRH-1, FXR?
4	MRP4 ABCC4	13q32 6.5 1325			NM 005845 LocusLink Swiss-Prot GeneCard	Mouse Rat	Many tissues	The human multidrug resistance protein MRP4 is an organic anion transporter that transports cyclic nucleotides and some nucleoside monophosphate analogs including nucleoside-based antiviral drugs (specificity similar to MRP5) MRP4 also transports prostaglandins.
5	MRP5 ABCC5	3q27 6.6 kB 1437 AA			NM 005688 NP 005679 LocusLink Swiss-Prot GeneCard	Mouse Rat	Many tissues Liver	The human multidrug resistance protein MRP5 is an organic anion transporter that transports cyclic nucleotides and some nucleoside monophosphate analogs including nucleoside-based antiviral drugs (specificity similar to MRP4)

6	MRP6 ABCC6	16p13.1 6.5 kB 1503 AA		Pseudoxanthoma elasticum	NM 001171 LocusLink Swiss-Prot GeneCard	Mouse Rat	Kidney Hepatocyte lateral membranes	In humans, MRP6 is highly expressed in the liver and kidney. Lower expression was found in tissues affected by pseudoxanthoma elasticum, including skin, retina, and vessel walls. Functional studies suggests that small peptides (BQ123) are transported by rat Mrp6. Recent studies show also transport of glutathione conjugates.

7	CFTR ABCC7	7q31.2 27 exons 6 kB 1480 AA		Mutations in this gene have been observed in patients with the autosomal recessive disorders Cystic Fibrosis (CF) and congenital bilateral aplasia of the vas deferens (CBAVD).	NM 000492 LocusLink Swiss-Prot GeneCard	Mouse Rat	Lung Intestine (crypt) Cholangiocytes apical membranes	This protein functions as a chloride channel and controls the regulation of other transport pathways.

8	SUR1 ABCC8	11p15.1 39 exons 5 kB 1581 AA		Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion.	NM 000352 LocusLink Swiss-Prot GeneCard	Mouse Rat	Pancreas	This protein functions as a modulator of ATP-sensitive potassium channels and insulin release.

9	SUR2 ABCC9	12p12.1 38 exons 5 kB 1549 AA		No disease has been associated with this gene thus far.	NM 005691 LocusLink Swiss-Prot GeneCard	Mouse Rat	Heart and skeletal muscle, with lower levels in all other tissues	This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels.

10	ABCC10 MRP7 ABCC10	6p21 22 exons 5.5 kB 1464 AA			NM033450 NP258261 LocusLink Swiss-Prot GeneCard	Mouse Rat	Low in all tissues	MRP7/ABCC7 has shown to transport estradiol(2)17beta glucuronide and less well also LTC4. E(2)17betaG transport was saturable, with Km and Vmax values of 57.8 microM and 53.1 pmol/mg/min.

11	ABCC11 MRP8 ABCC11	16q12.1 28 exons 4.6 kB 1382 AA			NM032583 NP115972 AF367202 NM033151 NP149163 NM145186 NP660187 LocusLink Swiss-Prot GeneCard	Mouse Rat	Low in all tissues Liver Breast	MRP8/ABCC11 is expressed at low levels in all tissues, except kidney, spleen, and colon. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Their chromosomal localization, potential function, and expression patterns identify them as candidates for paroxysmal kinesigenic choreoathetosis, a disorder characterized by attacks of involuntary movements and postures, chorea, and dystonia. Multiple alternatively spliced transcript variants have been described for this gene.

12	ABCC12 ABCC12	16q12 29 exons 5 kB 1359 AA		candidate for paroxysmal kinesigenic choreoathetosis, a disorder characterized by attacks of involuntary movements and postures, chorea, and dystonia.	NM033226 NP150229 NM145187 NP660188 NM145188 NP660189 NM145189 NP660190 NM145190 NP660191 LocusLink Swiss-Prot GeneCard	Mouse	Low in all tissues	ABCC12 is expressed at low levels in testes, ovary + prostate tissues. This gene and family member ABCC11 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not available.

13	ABCC13	21q11.2 14 exons 325 AA			NM138726 NP620054 NM172024 NP742021 NM172025 NP742022 NM172026 NP742023 LocusLink Swiss-Prot GeneCard		High expression in the fetal liver also bone marrow in peripheral blood leukocytes of adult humans much lower and no detectable levels in differentiated hematopoietic cells
ALD (subfamily D)
	Name/Symbol	Properties	Links	Phenotype	Access	Rodent	Tissue/Regulation	Function/Substrates
1	ALD ALDP ABCD1	Xq28 2.8 kB 745 AA		Defects in this gene have been identified as the underlying cause of Adrenoleuko- dystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system. Mutation DB GeneClinics	NM 000033 LocusLink Swiss-Prot GeneCard	Mouse Rat	Peroxisomes	This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids.

2	ALDL1 ALDR ABCD2	12q11 3.5 kB 740 AA		Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis.	NM 005164 LocusLink Swiss-Prot GeneCard	Mouse Rat	Peroxisomes	This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters.
							PPARa
3	PXMP1 PMP70 ABCD3	1p21-22 3.3 kB 659 AA		This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders.	NM 002858 NP002849 LocusLink Swiss-Prot GeneCard	Mouse Rat	Peroxisomes	This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter.
							PPARa
4	PXMP1L P70R ABCD4	14q24.3 2.9 kB 606 AA			NM005050 NP005041 NM020323 NP064719 NM020324 NP064720 NM020325 NP064730 NM020326 NP064731 LocusLink Swiss-Prot GeneCard	Mouse Rat	Peroxisomes	This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis.

OABP (subfamily E)
	Name/Symbol	Properties	Links	Phenotype	Access	Animals	Tissue/Regulation	Function/Substrates
1	RNASELI OABP ABCE1	4q31 2.9 kB 402 AA			NM 002940 LocusLink Swiss-Prot GeneCard	Mouse Rat	Ovary Testes Spleen	This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action.
GCN20 (subfamily F)
	Name/Symbol	Properties	Links	Phenotype	Access	Animals	Tissue/Regulation	Function/Substrates
1	ABC50 ABCF1	6p21.33 3.14 807			NM 001090 LocusLink Swiss-Prot GeneCard	Mouse Rat	All	Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process.
2	ABCF2 ABCF2	7q35-q36 2.2 kB 623 AA			NM 005692 LocusLink Swiss-Prot GeneCard	Mouse Rat	All	Iron inhibited ABC-transporter?
3	ABCF3 ABCF3	3q25.1 -q25.2 2.8 kB 709 AA			NM018358 NP060828 LocusLink Swiss-Prot GeneCard	Mouse Rat	All
White (subfamily G)
	Name/Symbol	Properties	Links	Phenotype	Access	Animals	Tissue/Regulation	Function/Substrates
1	ABCG1 ABC8 White ABCG1	21q22.3 AB038161 2.7 kB 638 AA			NM 004915 LocusLink Swiss-Prot GeneCard	Mouse Rat	Brain Spleen Lung	ABCG1 is involved in macrophage cholesterol efflux and may regulate cellular lipid homeostasis in other cell types.
							LXRa, PPARg ZNF202 (repressor) SHP (repressor by binding to LXR)
2	ABCG2 BCRP1 MXR1 ABCP ABCG2	4q22 2.4 kB 655 AA			NM 004827 LocusLink Swiss-Prot GeneCard	Mouse Rat	Placenta Breast Liver Intestine apical membranes	This protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Recently it has been shown to transport organic anions but also steroids (cholesterol, estradiol, progesterone, testosterone) and certain chlorophyll metabolites.

3	ABCG3? ABCG3? no human gene?	8p12 ?			LocusLink GeneCard	Mouse Rat	In mouse high in spleen and thymus	No human gene was found until now. High levels of expression in the thymus and spleen in mice suggest a potential role in the transport of specific peptides or hydrophobic compounds from lymphocytes.
4	ABCG4 White 2 ABCG4	11q23.3 3.5 kB 627 AA			NM 022169 LocusLink Swiss-Prot GeneCard	Mouse Rat	Macrophage Brain Eye Spleen
							LXRa
5	ABCG5 White 3 Sterolin1 ABCG5	2p21 2.3 kB 651 AA		Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with Sitosterolemia.	NM 022436 NP071881 LocusLink Swiss-Prot GeneCard	Mouse Rat	Liver Small Intestine Apical	ABCG5 functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8.
							LXRa
6	ABCG8 White 4 Sterolin2 ABCG8	2p21 2 kB 673 AA		Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with Sitosterolemia.	NM 022437 NP071882 LocusLink Swiss-Prot GeneCard	Mouse Rat	Liver Small Intestine Apical	ABCG8 functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5.
							LXRa

Thanks to Rando Allikmets, Susan Cole, Michael Dean, Stefan Gruenwald, Toshihisa Ishikawa, Wolfgang Kaminski, Stephan Kemp, Dietrich Keppler, Marcia Lachtermacher, Thomas Langmann, Roland Lill, Amanda Lumsden, Lorella Pascolo, Mustafa Porsch-Özürümez, Wolfgang Sattler, Erasmus Schneider, Steve Sutton, Hester Wain for helpful comments and support.

Name	ABC1	MDR	MRP	ALD	OABP	GCN20	White
Subfamily	ABCA	ABCB	ABCC	ABCD	ABCE	ABCF	ABCG
Members	12	11	13	4	1	3	5 (+ 1?)

	Fly	Worm	Yeast	Plant Arabidopsis	Mouse	Human
ABC-Transporter Genes	56	56	31	129	51	49