| 49 Human ATP-Binding Cassette Transporters |
| Name | ABC1 | MDR | MRP | ALD | OABP | GCN20 | White |
| Subfamily | ABCA | ABCB | ABCC | ABCD | ABCE | ABCF | ABCG |
| Members | 12 | 11 | 13 | 4 | 1 | 3 | 5 (+ 1?) |
I have to apologize, but somehow the
page disappeared from my site.
I found a version back in the web archive but it is not up-to-date, I will do my
best to update it again! Be patient, will keep you informed.
with symbols according to the nomenclature for human ABC-transporter
genes
( with links to M. Deans Book and
"Nice"Swiss-Prot and other updates)
Thanks for support! Suggestions/Comments are welcome!
Hosted by the Nutrition,
Metabolism and Genomics Group, Wageningen University, The
Netherlands
| Name/Symbol | Properties | Links | Phenotype | Access | Animals | Tissue/Regulation | Function/Substrates | |
| 1 |
ABC1 TGD HDLDT1 CERP |
9q22-q31 52 Exons SeqView 6.9 kB 2261 AA |
|
|
NM005502 |
Mouse Rat |
Many
tissues
|
|
| LXRa | ||||||||
| 2 | ABCA2 ABCA2 |
9q34 48 Exons SeqView 8 kB 2436 AA |
|
|
NM001606 |
Mouse Rat |
Brain Kidney Lung Heart |
|
| 3 | ABCA3 ABC-C ABCA3 |
16p13.3 SeqView 6.5 kB 1704 AA |
|
|
NM001089 |
Mouse Rat |
Lung + other tissues |
|
| 4 | ABCR RP19, ABC10 FFM, STGD1 STGD, RIM, RMP |
1p22 50 Exons. SeqView 7.3 kB 2273 AA |
|
|
NM000350 |
Mouse Rat |
Retina, photoreceptor cells |
|
| 5 | ABCA5 ABCA5 |
17q21-q24 6.5 kB 1642 AA |
|
NM018672 |
Mouse Rat |
Muscle Heart Testes upregulated in cultured hepatocytes |
|
|
| 6 | ABCA6 ABCA6 |
17q21 5.3 kB 1617 AA |
|
NM080284 |
Mouse Rat
|
Liver
|
|
|
| 7 | ABCA7 ABCX |
19p13.3 SeqView 6.6 kB 2146
AA |
|
|
NM019112 |
Mouse Rat |
Peripheral leukocytes, Thymus, Spleen, Bone marrow |
|
| 8 | ABCA8 ABCA8 |
17q24 5.7 kB 1581 AA |
|
NM007168 |
Mouse Rat |
Ovary |
|
|
| 9 | ABCA9 ABCA9 |
17q24 6 kB 1624 AA |
|
NM080283 |
Mouse Rat
|
Heart |
|
|
| 10 | ABCA10 ABCA10 |
17q24 6.18 kB 1543 AA |
|
Mouse Rat
|
Muscle Heart also in monocytes and M-CSF differentiated macrophages |
|
||
| 11 | ABCA12 ABCA12 |
2q35 7 kB 2595 AA |
|
|
NM015657 LocusLink Swiss-Prot GeneCard |
Mouse Rat
|
Stomach |
|
| 12 | ABCA13 ABCA13 |
7p11-q11 gene
450 kB |
|
|
NM152701 LocusLink Swiss-Prot GeneCard |
Mouse Rat
|
Major transcript shows highest expression in human trachea, testis, and bone marrow |
|
| Name/Symbol | Properties | Links | Phenotype | Access | Animal | Tissue/Regulation | Function/Substrates | |
| 1 | PGY1 MDR1 P-GP GP170 |
7q21 28 exons
4.5 1280 AA |
|
|
NM000927 |
Mouse Abcb1a Rat Abcb1a Mouse Abcb1b Rat Abcb1b |
Many
tissues (especially those with barrier functions such as liver, BBB,
kidney, intestine, placenta) apical membranes |
|
| 2 | TAP1 PSF1 RING4 ABC17 APT1 D6S114E |
6p21.3 11 exons 2.5 808 AA |
|
Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. |
NM000593 |
Mouse Rat |
Most
cells ER |
|
| 3 | TAP2 PSF2 RING11 D6S217E ABC18 |
6p21.3 11 ex. 2.8 653 |
| |||||