Nutrition, Metabolism and Genomics Group - Wageningen University - The Netherlands

Nutrition, Metabolism & Genomics Group
Head: Prof. dr. Michael Müller

The Nutrition, Metabolism and Genomics Group (Nutrigenomics Group) focuses on the nutritional regulation of metabolic pathways by nutrient-sensing nuclear receptors such as PPARs at the level of cells & organs. Currently, the nutrigenomics group is working on the regulatory effects of fatty acids & other nutrients on gene expression, metabolic & regulatory pathways & the functional implications of such regulation for homeostasis. We study how disturbances in these aspects (e.g. interaction with organ macrophages) contribute to local & systemic inflammation & ultimately to the development of the metabolic syndrome & related diseases. Particular attention is given to role of the intestine as important metabolic & immunological gatekeeper.
Education is offered at BSc, MSc and PhD level on metabolic and physiological mechanisms underlying the effects of nutrition on metabolism, integration & coordination of nutrient metabolism, & nutrigenomics & nutritional systems biology. The focus of the training programs is on the use of molecular biology tools in nutrition research.
Expertise & facilities include high-density microarray analysis (Affymetrix core lab with the newest Genetitan equipment) for whole genome gene expression analysis, large scale microarray database MADMAX & state-of-the-art bioinformatics & data mining tools (Ingenuity PA & Genomatix), a broad range of molecular biology tools & animal models including various transgenic mice.

"Dedicated to excellence in molecular nutrition & nutrigenomics research and progression of nutritional science towards nutritional science 2.0"

Recent papers (more):
c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile-duct-ligation in mice (Gastroenterology)
Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids (ATVB)
Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells (AJCN)
Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program (Plos ONE)
Dropping liver fat droplets (Hepatology)
Comparative analysis of gene regulation by the transcription factor PPARa between mouse and human (Plos ONE)
A saturated fatty acid rich diet induces an ‘obese-linked pro-inflammatory gene expression profile’ in adipose tissue of subjects at risk for metabolic syndrome (AJCN)
PPARβ/δ but not PPARα serves as plasma free fatty acid sensor in liver (Mol Cell Biol)
Kupffer cells promote hepatic steatosis via IL-1β dependent suppression of PPARa activity (Hepatology)
Bile salt sequestration induces hepatic de novo lipogenesis via FXR and LXR-controlled metabolic pathways in mice (Hepatology)
The potential influence of genetic variants in genes along bile acid and bile metabolic pathway on blood cholesterol levels in the population (Atherosclerosis)
Postprandial dietary lipid-specific effects on human peripheral blood mononuclear cell gene expression profiles (AJCN)
Transcriptional profiling reveals divergent roles of PPAR{alpha} and PPAR{beta}/{delta} in regulation of gene expression in mouse liver (Physiol Genomics)
Filling gaps in PPAR-alpha signaling through comparative nutrigenomics analysis (BMC Genomics)

Recent presentation at 19th International Nutrition Conference in Bangkok & Life Science Momentum 2009 (Den Haag) "Nutrigenomics: The path towards nutritional science 2.0"
Needed	Nutrigenomics Consortium NUGO NGI	Ingenuity Affymetrix MADMAX BioGPS	Over Genen en Genieten Inaugural lecture 2002 (pdf) Publications Faculty of 1000 (Contributor) Nutrigenomics Tweets	Students: Nutrigenomics & SysBiol Course Nuclear Receptor signaling
Nice		PubMedline Online Journals Nature Genomics Agralin Desktop library "Nutrigenomics"	Travel by Train (NS) Travel by Plane (KLM)	del.icio.us Spittoon Twitter Calorie Counter/NewCalorieCounter Nutrition nibbles blog Darwins Table
New	Eli Lilly PD2	Human Metabolome Database	1000Genomes	Worldmapper Flutracker

Address:	Prof. dr. Michael Müller Nutrition, Metabolism and Genomics group Division of Human Nutrition Wageningen University PO Box 8129 6700 EV Wageningen/ The Netherlands Phone +31-317-482590 Fax +31-317-483342 michael.muller@wur.nl

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