Nutrition, Metabolism
& Genomics Group |
 |
|
Nutrition, Metabolism
& Genomics Group |
|
|
| What is Nutrigenomics? Until recently, nutrition research concentrated on nutrient deficiencies and impairment of health. The advent of genomics -interpreted broadly as a suite of high-throughput technologies for the generation, processing, and application of scientific information about the composition and functions of genomes- has created unprecedented opportunities for increasing our understanding of how nutrients modulate gene and protein expression and ultimately influence cellular and organismal metabolism. Nutrigenomics can be seen as the combination of molecular nutrition and genomics. The diverse tissue and organ-specific effects of bioactive dietary components include gene expression patterns (transcriptome), organization of the chromatin (epigenome), protein expression patterns including post-translational modifications (proteome) as well as metabolite profiles (metabolome). Nutrigenomics will promote an increased understanding of how nutrition influences metabolic pathways and homeostatic control, how this regulation is disturbed in the early phases of diet-related disease, and the extent to which individual sensitizing genotypes contribute to such diseases. Eventually, nutrigenomics will lead to evidence-based dietary intervention strategies for restoring health and fitness and for preventing diet-related disease. (read for more Nature Reviews Genetics 4, 315-322 (2003)) (pdf) (recent review) | |
|
Je bent wat je eet, dat weten zelfs je genen (Volkskrant 21-6-2008) |
|
|
The
Nutrigenomics group studies the effects of
nutrients on gene expression and metabolic pathways with the focus on:
|
|
|
Two PhD positions
open: |
|
|
Recent papers (more): |
|
|
Address: |
Prof. dr. Michael Müller |
